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Systemic Corticosteroids Tied to Vaso-Occlusive Episodes in Sickle Cell – Consumer Health News

TUESDAY, April 26, 2022 (HealthDay News) — For sufferers with sickle cell illness (SCD), systemic corticosteroid publicity is related to an elevated danger for hospitalization for vaso-occlusive episodes (VOEs), in accordance with a examine revealed on-line April 26 in Blood.

Ondine Walter, from Toulouse University Hospital in France, and colleagues examined the chance for hospitalization for VOE related to systemic corticosteroid publicity in sufferers with SCD. A case-case-time management design was utilized in a nationwide population-based cohort constructed within the French nationwide medical health insurance database between 2010 and 2018; the design induces self-adjustment for time-invariant confounders, together with genotype. All sufferers with SCD with a minimum of one hospitalization for VOE have been included; the primary evaluation included 5,151 sufferers.

The researchers noticed a major affiliation between corticosteroid publicity and the prevalence of hospitalizations for VOEs (adjusted odds ratio, 3.8). The adjusted odds ratios have been 2.6 and 4.0 in sufferers uncovered to hydroxyurea and unexposed sufferers, respectively. In kids and adults, the outcomes have been constant.

“This nationwide population-based study showed an increased risk of hospitalization for VOE after out-of-hospital exposure to systemic corticosteroids,” the authors write. “The strength of the association was lower in men, in children, and in patients treated with hydroxyurea.”

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